Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes

Publication

Publication Type:

Journal Article

Source:

Biochimica et Biophysica Acta, Volume 1842, Issue 8 (2014)

Other Number:

PMID: 24060637

URL:

http://www.sciencedirect.com/science/article/pii/S092544391300286X

Keywords:

Mitochondria-targeted antioxidant; Mitochondrial dysfunction; Neuroprotection; Oxidative stress; Parkinson's disease

Abstract:

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial dysfunction and oxidative stress have a central role in the dopaminergic neurodegeneration of Parkinson's disease. In this context, mitochondria-targeted therapies that improve mitochondrial function may have great promise in the prevention and treatment of Parkinson's disease. In this review, we discuss the recent developments in mitochondria-targeted antioxidants and their potential beneficial effects as a therapy for ameliorating mitochondrial dysfunction in Parkinson's disease.